Welcome to the web home for the Department of Biophysics.  The Department of Biophysics is one of ten basic science departments in the Institute of Experimental Physics Slovak Academy of Science.  Basic biophysical, biochemical, and biomedical research are a key mission and activity in the Department.  Biophysics at IEP is wide ranging and covers many biological interests and biophysical techniques:

Protein stability (Prof. Marian Antalik, DrSc.).Our interest is devoted to the characterization of the structure and stability of various biomacromolecules (proteins, polynucleic acids, polysaccharides) in the presence of denaturants, salts and polyanions.  We also working on developing a new method for preparing the metal nanoparticles (Au, Ag, ZnO, Fe3O4) covered by various organic compounds, particularly peptides. We utilize different techniques to gain nanoparticles with exact atomic and structural composition. Those pure fractions of nanoparticles appears to form supramolecular structures with proteins

Amyloid structures (Zuzana Gazova, PhD.). Protein amyloid aggregation – Specific amyloid self-assemblies associated with pathogenesis of many diseases such as Alzheimer's and Parkinson's diseases and diabetes type II.  We have three long-term goals related to study the amyloid formation: I) to elucidate the mechanism of amyloid aggregation of amyloidogenetic proteins; II) to examinethe role of low-molecular substances and/or nanoparticles in depolimerization or inhibition of amyloid aggregation; and III) to determine the way how to detect the Alzheimer's disease in early stage.

Mitochondrial Oxidative Stress (Andrej Musatov, DrSc.).  Increased generation of reactive oxygen species (ROS) is known to be associated with a number of diseases, e.g., ischemia/reperfusion injury, neurodegenerative diseases, rheumatoid arthritis and age-related degeneration.  The mitochondrial electron transport chain is recognized as the major source of intracellular ROS.  Our goal is to elucidate mechanisms by which ROS damage individual components of electron-transfer complexes.

Electron Transport in Photosynthetic Reaction Centers (Michal Pudlák, PhD.). Photosynthesis is the source of energy for all life on earth and includes some of the fastest known chemical reactions. Using projector operator method we develop the general master equations which describe the electron transfer in photosynthetic reaction centerswhere the solar energy is converted into chemical energy. 

Biomedical image analysis (Zoltan Tomori, PhD.). Advanced computer vision techniques have growing importance in many areas of biomedicine, especially in microscopy. Our goal is the utilization of specific NUI devices, e.g. Microsoft Kinect, touch tablet to control the "state of the art" experimental devices such as optical tweezers and optical scalpel. Proposed algorithms allow not only recognition of microscopic particles, but also automatic or semi-automatic manipulation of them. The part of this process is appropriate visualization in mono or stereo mode that represents a feedback of interactive algorithms (read more in http://www.saske.sk/~tomori)

In general, our departmental research methodologies cover a broad spectrum of techniques and experimental approaches; employ state-of-the-art instrumentation for biological imaging and protein structural and functional analysis, including optical tweezers, atomic force microscopy, UV/VIS/IR spectrophotometer, spectrofluorimeters, differential scanning calorimeter and many others.

Thank you for your visit; explore our website and discover who we are and what we do.